Period: 2011

To address the paucity of population-based pregnancy data, the Global Network established a population-based Vital Registration System in 2009 to document fetal, neonatal, and maternal mortality, called the Maternal and Neonatal Health Registry Study. In addition to tracking outcomes over time to better understand mortality in these areas and plan interventions, the data can be used to develop public health policies.

Researchers

Principal Investigator: José Belizán
Co-investigators: Fernando Althabe (Institute of Clinical and Health Effectiveness – IECS- Buenos Aires), Pierre Buekens (Tulane University, United States),
General Coordinator: Mabel Berrueta (Institute of Clinical and Health Effectiveness – IECS- Buenos Aires)
Data management: Álvaro Ciganda (Montevideo Clinical and Epidemiological Research Unit, Uruguay)
Statistics: Luz Gibbons (Institute of Clinical and Health Effectiveness – IECS- Buenos Aires)
Regional Coordinator in Corrientes: Enzo Montenegro
Regional Coordinator in Santiago del Estero: Ana María Dominguez

Hospital data collectors:

Virasoro: Alicia González and María Cristina Ganduglia
Mercedes: Tania Etcheverría de Lima
Corner: Liliana González, Maria José Pellegrino
Quimili: Diego Espinosa, Lucas Urquiza
Add: Rita Agüero
Frias: Andrea Barea

Summary

The main objective of the study is to quantify and understand trends in perinatal outcomes in low-resource geographic areas over time, with the intention of providing population-based statistics on fetal, neonatal, and maternal mortality. By obtaining a vital registration system, maternal and neonatal mortality will be documented, which will allow studies to be designed to evaluate the main causes of these adverse outcomes and disseminate the results to be used as a basis for modifying health policies.

Type of research: Observational, Prospective, population-based.

Inclusion criteria:

At the community level:

It must be appropriate for long-term recording of data and for the conduct of the study.
At least 300 births per year.

At the women's level:

Women who give birth in one of the included communities.
Women who reside in one of the included communities but who are transferred to another place at the time of childbirth.

Exclusion criteria

At the women's level:

Women who do not provide consent to include their data in the study

Duration of the study: At least 5 years.

Location: This is a study designed by researchers from the Global Network for Research in Women's and Children's Health, made up of 10 consortia each made up of institutions from developing countries in Latin America, Africa and Asia and one institution from the United States. Joined. Site 1 of the Global Network is made up of the IECS (Argentina) and Tulane University, USA. In Argentina, 6 geographic areas were selected (3 in the Province of Corrientes and 3 in Santiago del Estero) appropriate for data collection and conduct of the study.

Ethical evaluation: The study was approved by the Institutional Review Board (IRB) of Tulane University, USA, and by the Ethics Committee of CEMIC, Buenos Ares, Argentina.

Objectives

Quantify and understand trends in perinatal outcomes in low-resource geographic areas over time, with the intention of providing population-based statistics on fetal, neonatal, and maternal mortality.

Finance

National Institute of Child Health and Human Development (NICHD), United States.

Study design

Observational, Prospective, population-based

Publications

H, Hartwell TD, Moore J, Wright LL; First Breath Study Group. High mortality rates for very low birth weight infants in developing countries despite training. Pediatrics. 2010 Nov;126(5):e1072-80

Carlo WA, Goudar SS, Jehan I, Chomba E, Tshefu A, Garces A, Parida S, Althabe F, McClure EM, Derman RJ, Goldenberg RL, Bose C, Krebs NF, Panigrahi P, Buekens P, Chakraborty H, Hartwell TD , Wright LL; First Breath Study Group. Newborn-care training and perinatal mortality in developing countries. N Engl J Med. 2010 Feb 18;362(7):614-23.

Pasha O, Goldenberg RL, McClure EM, Saleem S, Goudar SS, Althabe F, Patel A, Esamai F, Garces A, Chomba E, Mazariegos M, Kodkany B, Belizan JM, Derman RJ, Hibberd PL, Carlo WA, Liechty EA , Hambidge KM, Buekens P, Wallace D, Howard-Grabman L, Stalls S, Koso-Thomas M, Jobe AH, Wright LL. Communities, birth attendants and health facilities: a continuum of emergency maternal and newborn care (the Global Network's EmONC trial). BMC Pregnancy Childbirth. 2010 Dec 14;10:82

McClure EM, Pasha O, Goudar SS, Chomba E, Garces A, Tshefu A, Althabe F, Esamai F, Patel A, Wright LL, Moore J, Kodkany BS, Belizan JM, Saleem S, Derman RJ, Carlo WA, Hambidge KM , Buekens P, Liechty EA, Bose C, Koso-Thomas M, Jobe AH, Goldenberg RL; Global Network Investigators. Epidemiology of stillbirth in low-middle income countries: a Global Network Study. Acta Obstet Gynecol Scand. 2011 Dec;90(12):1379-85

Althabe F, Belizán JM, Mazzoni A, Berrueta M, Hemingway-Foday J, Koso-Thomas M, McClure E, Chomba E, Garces A, Goudar S, Kodkany B, Saleem S, Pasha O, Patel A, Esamai F, Carlo WA, Krebs NF, Derman RJ, Goldenberg RL, Hibberd P, Liechty EA, Wright LL, Bergel EF, Jobe AH, Buekens P. Antenatal corticosteroids trial in preterm births to increase neonatal survival in developing countries: study protocol. Reprod Health. 2012 Sep 19 ; 9:22

Goudar SS, Carlo WA, McClure EM, Pasha O, Patel A, Esamai F, Chomba E, Garces A, Althabe F, Kodkany B, Sami N, Derman RJ, Hibberd PL, Liechty EA, Krebs NF, Hambidge KM, Buekens P , Moore J, Wallace D, Jobe AH, Koso-Thomas M, Wright LL, Goldenberg RL.

The Maternal and Newborn Health Registry Study of the Global Network for Women's and Children's Health Research. Int J Gynaecol Obstet. 2012 Sep;118(3):190-3

Belizán JM, McClure EM, Goudar SS, Pasha O, Esamai F, Patel A, Chomba E, Garces A, Wright LL, Koso-Thomas M, Moore J, Althabe F, Kodkany BS, Sami N, Manasyan A, Derman RJ, Liechty EA, Hibberd P, Carlo WA, Hambidge KM, Buekens P, Jobe AH, Goldenberg RL. Neonatal death in low- to middle-income countries: a global network study. Am J Perinatol. 2012 Sep;29(8):649-56

Pasha O, McClure EM, Wright LL, Saleem S, Goudar SS, Chomba E, Patel A, Esamai F, Garces A, Althabe F, Kodkany B, Mabeya H, Manasyan A, Carlo WA, Derman RJ, Hibberd PL, Liechty EK , Krebs N, Hambidge KM, Buekens P, Moore J, Jobe AH, Koso-Thomas M, Wallace DD, Stalls S, Goldenberg RL. A combined community- and facility-based approach to improve pregnancy outcomes in low-resource settings: a Global Network cluster randomized trial. BMC Med. 2013 Oct 3;11(1):215

Manasyan A, Saleem S, Koso-Thomas M, Althabe F, Pasha O, Chomba E, Goudar SS, Patel A, Esamai F, Garces A, Kodkany B, Belizan J, McClure EM, Derman RJ, Hibberd P, Liechty EA, Hambidge KM, Carlo WA, Buekens P, Moore J, Wright LL, Goldenberg RL; EmONC Trial Group. Assessment of obstetric and neonatal health services in developing country health facilities. Am J Perinatol. 2013 Oct;30(9):787-94

Marete I, Tenge C, Pasha O, Goudar S, Chomba E, Patel A, Althabe F, Garces A, McClure EM, Saleem S, Esamai F, Kodkany BS, Belizan JM, Derman RJ, Hibberd PL, Krebs N, Buekens P , Goldenberg RL, Carlo WA, Wallace D, Moore J, Koso-Thomas M, Wright LL, Liechty EA. Perinatal Outcomes of Multiple-Gestation Pregnancies in Kenya, Zambia, Pakistan, India, Guatemala, and Argentina: A Global Network Study. Am J Perinatol. 2013 Mar 19.